The triphenylmethyl (trityl) group and its uses in nucleotide chemistry |
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| Authors: | V Kohli H Blöcker H Köster |
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| Institution: | Institute of Organic Chemistry and Biochemistry University of Hamburg, Martin-Luther-King-Platz 6, D-2000 Hamburg 13, FRG |
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| Abstract: | The triphenylmethyl (trityl) group can be removed from 5′-trityl 2′-deoxynucleosides (and their N-acyl derivatives) under aprotic neutral conditions without causing any side reactions. An efficient method for tritylation of N-acyl 2′-deoxynucleosides is described. Potential use of such derivatives for stepwise synthesis of deoxyoligonucleotides is discussed. |
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