Asymmetric alkylation of an α-keto ester with chiral lithium alkoxy-tributylaluminates |
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Authors: | D Abenhaïm G Boireau B Sabourault |
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Institution: | Laboratoire de Chimie Organométallique, Université de Paris-Sud, Centre d''Orsay 91405 Orsay France |
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Abstract: | Lithium tetrabutylaluminate modified by either (-)-N-methylephedrine or Darvon alcohol(*)-(2S, 3R)-4-dimethylamino-3-methyl-1,2-diphenyl-2-butanol] readily reacts with phenylglyoxylic acid methyl ester to give the expected α-butyl α-hydroxy ester with a good chemical yield and an optical yield of 43% when Darvon alcohol is used. |
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