Synthesis and characterization of ratiometric nanosensors for pH quantification: a mixed micelle approach |
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Authors: | Kumar E K Pramod Almdal Kristoffer Andresen Thomas L |
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Institution: | Technical University of Denmark, Department for Micro- and Nanotechnology, DTU Nanotech, 2800 Lyngby, Denmark. |
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Abstract: | Optical nanoparticle pH sensors designed for ratiometric measurements have previously been synthesized using post-functionalization approaches to introduce sensor molecules and to modify nanoparticle surface chemistry. This strategy often results in low control of the nanoparticle surface chemistry and is prone to batch-to-batch variations, which is undesirable for succeeding sensor calibrations and cellular measurements. Here we provide a new synthetic approach for preparing nanoparticle pH sensors based on self-organization principles, which in comparison to earlier strategies offers a much higher design flexibility and high control of particle size, morphology and surface chemistry. |
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