Resorbable scaffolds from three different techniques: electrospun fabrics, salt-leaching porous films, and smooth flat surfaces |
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Authors: | Finne-Wistrand Anna Albertsson Ann-Christine Kwon Oh Hyeong Kawazoe Naoki Chen Guoping Kang Inn-Kyu Hasuda Hirokazu Gong Jiansheng Ito Yoshihiro |
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Institution: | Department of Fibre and Polymer Technology, Royal Institute of Technology, SE-100 44 Stockholm, Sweden. |
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Abstract: | Nanofibrous scaffolds of poly(L-lactide)-co-(1,5-dioxepan-2-one)] generated by electrospinning have been compared with porous films obtained by solvent cast/salt leaching and homogeneous films. A comparison between the fibrous materials and the homogeneous solvent-cast films revealed that the surface of the nanofibers was more hydrophobic and that the nanofibers were degraded more rapidly in the presence of proteinase. It was obvious that the strain-to-break was reduced by the nanofiber formation, it decreased from 370% to 130% independent of fiber diameter. These values were however considerably higher than the strain-to-break of the solvent-cast/salt leaching scaffold. In addition, the nanofibrous material accelerated the adhesion and growth of the mesenchymal stem cell compared to the smooth material. |
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Keywords: | cell proliferation degradation electrospinning structure/property relations tissue engineering |
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