A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues |
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| Authors: | Dhar T G Murali Guo Junqing Shen Zhongqi Pitts William J Gu Henry H Chen Bang-Chi Zhao Rulin Bednarz Mark S Iwanowicz Edwin J |
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| Institution: | Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-4000, USA. dharm@bms.com |
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| Abstract: | structure: see text] A modified approach to the synthesis of 2-(N-aryl)-1,3-oxazoles, employing an optimized iminophosphorane/heterocumulene-mediated methodology, and its application to the synthesis of BMS-337197, a potent inhibitor of IMPDH, are described. |
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