A practical synthesis of 2′-aminoacylamino-2′-deoxyadenosines |
| |
Authors: | Gavin O'Mahony |
| |
Institution: | Department of Chemistry—Medicinal Chemistry, Göteborg University, SE-412 96 Göteborg, Sweden |
| |
Abstract: | A practical and efficient synthesis of 2′-aminoacylamino-2′-deoxyadenosine derivatives is reported. EDCI/HOBt-mediated coupling of a 3′,5′-diprotected 2′-amino-2′-deoxyadenosine derivative to various N-Cbz-l-amino acid derivatives followed by global deprotection affords analytically pure 2′-aminoacylamino-2′-deoxyadenosine derivatives without the necessity for preparative HPLC purification. These compounds are non-hydrolysable isosteres of 2′-aminoacyladenosines, which are of use in X-ray studies for the elucidation of the editing mechanism of various tRNA synthetases. |
| |
Keywords: | tRNA synthetases 2&prime -Aminoacylamino-2&prime -deoxyadenosine derivatives |
本文献已被 ScienceDirect 等数据库收录! |