Iron(III) chloride-catalyzed convenient one-pot synthesis of β-acetamido carbonyl compounds |
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Authors: | Abu T Khan Tasneem Parvin Lokman H Choudhury |
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Institution: | Indian Institute of Technology Guwahati, Department of Chemistry, Guwahati 781 039, India |
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Abstract: | A one-pot multi-component reaction of aldehydes, enolizable ketones or 1,3-dicarbonyls, acetonitrile/benzonitrile, and acetyl chloride is described for the preparation of β-acetamido carbonyl compounds using FeCl3·6H2O as a mild, inexpensive, and highly efficient catalyst. The effect of substrate as well as substituent for multi-component reaction versus Knoevenagel condensation is also illustrated. The key features of this methodology are operational simplicity, mild reaction conditions, and good yields. |
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