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Three multicomponent reactions of 3,5-dimethyl-4-nitroisoxazole |
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| Authors: | Mauro FA Adamo Vivekananda R Konda Piero Sarti-Fantoni |
| Institution: | a Centre for Synthesis and Chemical Biology (CSCB), Department of Pharmaceutical and Medicinal Chemistry, The Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Dublin, Ireland b Dipartimento di Chimica, Università di Siena, Via Aldo Moro, Siena 53100, Italy c Dipartimento di Chimica Organica ‘U. Schiff’, Università di Firenze, Via della Lastruccia, Sesto Fiorentino 50019, Italy d Quìmica Organica, Facultad de Ciencias, Universidad de Burgos, 09001 Burgos, Spain |
| Abstract: | The title compound is used to prepare 3-arylglutaric acids, bis-isoxazoles and bis-pyrazoles from commercially available materials. The methodologies described have afforded important synthetic intermediates in high yields and without the use of chromatography. |
| Keywords: | Isoxazoles Polyfunctional scaffold Pyrazoles Glutaric acid derivatives |
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