Asymmetric construction of chiral C-N axes through rhodium-catalyzed 1,4-addition |
| |
Authors: | Wei-Liang Duan Tamio Hayashi |
| |
Affiliation: | Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan |
| |
Abstract: | Catalytic asymmetric construction of chiral C-N axes has been developed through a rhodium-catalyzed asymmetric 1,4-addition reaction. Both central chirality and axial chirality have been controlled at the same time using Rh/(R,R)-Ph-bod∗ catalyst with high enantio- and diastereoselectivity. This method has also been applied to the preparation of a planar-chiral ferrocene derivative. The resulting chiral C-N axis can be used as a good template to control the stereochemistry in the subsequent transformations such as alkylation and Diels-Alder reactions. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|