Synthesis of enantiomeric bridgehead substituted bisnoradamantane derivatives |
| |
| Authors: | Carles Ayats Mercè Font-Bardia Santiago Vázquez |
| |
| Institution: | a Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain
b Serveis Cientifico-Tècnics, Universitat de Barcelona, Av. Martí Franquès, s/n, Barcelona E-08028, Spain |
| |
| Abstract: | The preparation of (+)- and (−)-12 by resolution of (±)-12 with (R)-N-phenylpantolactam, (R)-13, is described. From (+)- and (−)-12 a series of chiral bisnoradamantane derivatives, whose chirality stems from substitution at the bridgehead positions, have been obtained in both enantiomeric forms. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
