Lewis acid promoted Mannich type reactions of α,α-dichloro aldimines with potassium organotrifluoroborates |
| |
Authors: | Sara Stas |
| |
Institution: | Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium |
| |
Abstract: | Potassium phenylethynyltrifluoroborate and potassium styryltrifluoroborates react with α,α-dichlorinated aldimines in the presence of BF3·OEt2 as a Lewis acid to give a new stable class of functionalized propargylamines and allylamines. The use of hexafluoroisopropanol as a co-solvent in this modified Petasis reaction allows high yield isolation of the target compounds. |
| |
Keywords: | Boron Imines Addition reactions Mannich bases |
本文献已被 ScienceDirect 等数据库收录! |
|