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Isoquinolone derivatives via a furan recyclization reaction |
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| Authors: | Artem S Dmitriev Wolfgang Bender |
| Institution: | a Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Moskovskaya St. 2, Krasnodar 350072, Russian Federation b North-Ossetian State University, Vatutina 46, Vladikavkaz 362025, Russian Federation c Bayer HealthCare AG, D-51368 Leverkusen, Germany |
| Abstract: | A new approach to the synthesis of isoquinolone derivatives has been developed. It is based on the protolytic recyclization of amides of 2-carboxybenzylfurans. It was shown that the reaction proceeds via formation of allylic alcohols of isoquinolone series, which under acidic conditions undergo isomerization into the corresponding ketones. A new condensed heterocyclic system of furo2′,3′:3,4]cyclohepta1,2-c]isoquinolin-8(6H)-one has been synthesized. |
| Keywords: | Furan Recyclization Isoquinolone |
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