Diastereoselective addition of α-substituted α-amino-H-phosphinates to imines using Yb(OTf)3 as an efficient Lewis acid catalyst |
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| Authors: | Babak Kaboudin Terumitsu Haruki Tsutomu Yokomatsu |
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| Institution: | a Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Gava Zang, Zanjan 45195-1159, Iran
b School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan |
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| Abstract: | Diastereoselective addition of α-substituted α-amino-H-phosphinates to imines is described. Among Lewis acids, Yb(OTf)3 was found to be the best catalyst. α,α′-Diaminophosphinic derivatives were obtained with de's ranging from 10 to 95% in the presence of Yb(OTf)3 as an efficient Lewis acid catalyst. The reaction proceeded with retention of configuration at the phosphorus atom. |
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