A regioselective route to 5-substituted pyrazole- and pyrazoline-3-phosphonic acids and esters |
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| Authors: | P. Conti A. Pinto V. Rizzo |
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| Affiliation: | a Istituto di Chimica Farmaceutica e Tossicologica ‘P. Pratesi’, Università degli Studi di Milano, Viale Abruzzi 42, 20131 Milano, Italy
b CISI, Università degli Studi di Milano, Via Fantoli 16/15, 20138 Milano, Italy |
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| Abstract: | The regioselective synthesis of 5-substituted-3-dimethoxyphosphono-pyrazoles and -2-pyrazolines has been accomplished through the 1,3-dipolar cycloaddition of a suitable nitrile imine to monosubstituted alkynes and alkenes. Examples of hydrolysis of the heterocyclic phosphonic esters to the corresponding acids are described. |
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