An air-stable chiral Hf-based catalyst for asymmetric Mannich-type reactions |
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| Authors: | Shū Kobayashi Ryo Yazaki Kazutaka Seki Masaharu Ueno |
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| Affiliation: | Department of Chemistry, School of Science, Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science Technology Agency (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan |
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| Abstract: | A new class of isolable, air-stable, storable, and Hf-based catalyst has been developed. In the presence of 10 mol % of the powdered Hf catalyst, the asymmetric Mannich-type reactions of imines with silicon enolates derived from esters proceeded smoothly to afford the corresponding Mannich-type adducts in high yields with high enantioselectivities. Hafnium single crystals for X-ray analysis were obtained, and the crystals also showed high performance in the asymmetric Mannich-type reactions. |
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| Keywords: | Hafnium Asymmetric catalysis Imines Mannich-type reactions |
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