Convergent total synthesis of squamostolide |
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| Authors: | Kevin J Quinn Austin G Smith Carolyn M Cammarano |
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| Institution: | Department of Chemistry, College of the Holy Cross, One College Street, Worcester, MA 01610-2395, USA |
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| Abstract: | A convergent total synthesis of the Annonaceous acetogenin squamostolide, in a longest linear sequence of nine steps from d-mannitol, is reported. Central to the efficiency of the synthesis is a highly selective tandem ring-closing/cross metathesis step in which lactone formation and fragment coupling are accomplished. |
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| Keywords: | Squamostolide Annonaceous acetogenin Total synthesis Olefin metathesis |
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