Effect of substituent structure on pyrimidine electrophilic substitution |
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Authors: | Christiaan W. van der Westhuyzen Amanda L. Rousseau Christopher J. Parkinson |
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Affiliation: | Discovery Chemistry, CSIR Biosciences, Building T5, Pinelands Site, Ardeer Road, Pinelands 1645, South Africa |
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Abstract: | In an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these were chloro-, mono- or disubstituted amino groups. Effects such as the presence of an aryl group or two alkyl groups on the amino moiety impede the progress of the reaction despite the presence of a second activating group. |
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Keywords: | Pyrimidine Nitrosation Alkyl substituted Aryl substituted |
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