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Toward new camptothecins. Part 4: On the reactivity of nitro and amino precursors of aza analogs of 5-methoxycarbonyl camptothecin |
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| Authors: | Laurent Gavara Daniel Couturier Jean-Pierre Hénichart |
| Institution: | a Ecole des Hautes Etudes d'Ingénieur, EA 2692, 13 rue de Toul, 59046 Lille, France b Laboratoire d'Ingéniérie Moléculaire, Université des Sciences et Technologies de Lille 1, 59655 Lille, France c Institut de Chimie Pharmaceutique Albert Lespagnol, EA2692, Université de Lille 2, rue du Professeur Laguesse, BP 83 F-59006 Lille, France |
| Abstract: | In the context of formation of new aza analogs of camptothecin, nitration then reduction of condensed pyridones was realized, leading to new derivatives of pyrrolo-aza-indoles. Treatment of these compounds with hydrobromic acid led to new structure rearrangements while oxidation of the α-position was unsuccessful. Mechanisms of formation of the new products are discussed. |
| Keywords: | 2-Pyridone Camptothecin Decarboxylation Nitro displacement |
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