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Synthesis of pyrimidine-5-carbaldehydes from α-formylaroylketene dithioacetals |
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| Authors: | Annie Mathews C.V. Asokan |
| Affiliation: | a Baselius College, Chemistry Department, Kottayam, Kerala 686001, India b School of Chemical Sciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, Kerala 686560, India |
| Abstract: | A facile one pot synthetic path for the preparation of pyrimidine-5-carbaldehydes from α-formylaroylketene dithioacetals is described. Amidines were allowed to react with α-formylaroylketene dithioacetals in DMF or acetonitrile to afford the pyrimidine-5-carbaldehydes. The starting compounds reported earlier were synthesized from α-oxoketene dithioacetals in excellent amount. |
| Keywords: | Pyrimidine-5-carbaldehydes α-Formylaroylketene dithioacetals α-Oxoketene dithioacetals Amidines |
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