|
|||||
|
|
Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water |
|
| Authors: | Meng Lei Gong Li Weihai Fang Zemei Ge Runtao Li |
| Institution: | a School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, PR China c Department of Chemistry, Beijing Normal University, Beijing 100875, PR China |
| Abstract: | The l-proline-based dipeptide has been discovered and developed as an efficient catalyst for the direct asymmetric aldol reactions of unmodified ketones with various aldehydes including aromatic, aliphatic, heteroaromatic, and unsaturated aldehydes in the presence of water at 0 °C. The resulted methodology and optimal conditions led to the corresponding aldol products with high yields (up to 94%) and good enantioselectivities (up to 97% ee). |
| Keywords: | Organocatalysis Asymmetric aldol reaction Dipeptide In the presence of water |
| 本文献已被 ScienceDirect 等数据库收录！ | |