| 1,4-二氢吡啶衍生物与DNA相互作用的电化学与圆二色谱研究 |
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| 引用本文： | 杜江燕,王炳祥,徐飞,陈婷婷,沈珠英,沈永淼,邢巍,陆天虹. 1,4-二氢吡啶衍生物与DNA相互作用的电化学与圆二色谱研究[J]. 高等学校化学学报, 2005, 26(4): 663-666 |
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| 作者姓名： | 杜江燕 王炳祥 徐飞 陈婷婷 沈珠英 沈永淼 邢巍 陆天虹 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所, 长春 130022;2. 南京师范大学化学与环境科学学院, 南京 210097 |
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| 基金项目： | 江苏省教育厅自然科学基金;国家"211"工程建设项目 |
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| 摘 要： | 用电化学和圆二色谱(CD)技术研究了5个1,4-二氢吡啶(1,4-DHP)衍生物与小牛胸腺DNA(CT-DNA)的相互作用.结果表明,1,4-DHP衍生物与CT-DNA相互作用是通过嵌入的方式进行的,相互作用的强弱与1,4-DHP衍生物的立体结构有关.1,4-DHP衍生物4-取代基空间位阻越小,嵌入到CT-DNA的程度越大.相反,空间位阻较大的1,4-DHP衍生物嵌入CT-DNA程度较小.非平面结构的1,4-DHP衍生物使CT-DNA双螺旋链结构松散程度增大.
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| 关 键 词： | 二氢吡啶衍生物 DNA 电化学 圆二色谱 氧化峰 DNA构象 |
| 文章编号： | 0251-0790(2005)04-0663-04 |
| 收稿时间： | 2004-04-28 |
Voltammetric and Circular Dichroism Studies on Interaction Between 1, 4-Dihydropyridine Derivatives and DNA |
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| DU Jiang-Yan,WANG Bing-Xiang,XU Fei,CHEN Ting-Ting,SHEN Zhu-Ying,SHEN Yong-Miao,XING Wei,LU Tian-Hong. Voltammetric and Circular Dichroism Studies on Interaction Between 1, 4-Dihydropyridine Derivatives and DNA[J]. Chemical Research In Chinese Universities, 2005, 26(4): 663-666 |
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| Authors: | DU Jiang-Yan WANG Bing-Xiang XU Fei CHEN Ting-Ting SHEN Zhu-Ying SHEN Yong-Miao XING Wei LU Tian-Hong |
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| Affiliation: | 1. Changchun Institute of Applied Chemistry, Chinese Acdemy of Sciences, Changchun 130022, China;2. College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China |
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| Abstract: | The interactions of five kinds of 1,4-dihydropyridine(1,4-DHP) derivatives with calf thymus DNA(CT-DNA) were investigated by the electrochemical method and circular dichroism(CD). The results indicated that the interaction between 1,4-DHP derivatives and CT-DNA was in the intercalative mode. The strength of the interaction increases with the decrease in the steric hindrance of 1,4-DHP derivatives. DNA double helix in solution become more loose in the presence of non-planar structure 1,4-DHP derivatives. |
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| Keywords: | DNA |
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