An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines |
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| Authors: | Haiying Tian Ruiyan Li Dr. Fang Guo Dr. Xiuling Chen |
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| Affiliation: | 1. Department of Pharmacy, Changzhi Medical College, 046000 Changzhi P. R. China ; 2. Department of Materials Science and Engineering, Jinzhong University, 030619 Jinzhong P. R. China |
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| Abstract: | Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH4I‐mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups. |
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| Keywords: | sulfonamides sodium sulfinates NH4I green protocols metal-free |
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