Optimization of INEPT and DEPT experiments for spin systems with hetero- and homonuclear couplings |
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| Affiliation: | 1. Bruker UK Ltd., Banner Lane, Coventry CV4 9GH, United Kingdom;2. TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research Hyderabad, 36/P Gopanpally Village, Ranga Reddy District, Hyderabad 500107, India;1. Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, 625 N. Michigan Ave., 14th Floor, Chicago, IL, 60611, USA;2. Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, 722 West 168th St., New York City, NY 10032, USA;1. Centre for Research in Environmental Epidemiology, Barcelona, Spain;2. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain;3. Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain;4. Physical Activity and Sports Sciences Department, Fundació Blanquerna, Barcelona, Spain;5. Center for Environmental Policy, Imperial College London, London, United Kingdom;6. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina;7. Environmental Health Sciences, School of Public Health, University of California, Berkeley, California;1. Institute of Environmental Technology, CEET, VŠB – Technical University of Ostrava, 17. listopadu 15/2172, 708 00 Ostrava, Czech Republic;2. Faculty of Material Science and Technology, Department of Chemistry, VŠB – Technical University of Ostrava, 17. listopadu 15/2172, 708 00 Ostrava, Czech Republic;3. Universidad Nacional de Tumbes, Faculdad de Ciencias Agrarias, Departamento de Ingeniería Forestal y Gestión Ambiental, Ciudad Universitario s/n Pampa Grande, Tumbes, Peru;1. Bruker UK Ltd., Banner Lane, Coventry CV4 9GH, United Kingdom;2. TIFR Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research-Hyderabad, 36/P Gopanpally Village, Ranga Reddy District, Hyderabad 500 046, Telangana, India;3. Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, Netherlands;4. Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK |
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| Abstract: | The application of INEPT and DEPT pulse sequences to weakly coupled spin- systems with different hetero- and homonuclear coupling constants has been investigated. For the simulation of the spectra arising from these multiple-pulse experiments, general computer programs have been written based on the density matrix approach. Numerical results calculated in this way allow the investigation of the polarization transfer in detail. Analytical expressions which describe the attainable sensitivity enhancement are presented. Their use in the experimental optimization of these pulse sequences is demonstrated for 13C and 15N NMR spectra. |
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