| Syntheses of Macrocyclic Amides from L-Amino Acid Esters by RCM |
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| 作者姓名： | ZHAO Bao-xiang SCHAUDT Marco BLECHERT Siegfried |
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| 作者单位： | [1]Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P.R. China; [2]Institut fuer Chemie, Technische Universittit Berlin, Strasse des 17. Juni 135, D-10623 Berlin, Germany |
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| 摘 要： | IntroductionThe discovery of stable and defined carbenecomplexes of molybdenum and ruthenium as efficientprecatalysts for olefin metathesis has made this transfor-mation one of the most important C—C bond formingreactions1—11]. Specifically, ring-closi…
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| 关 键 词： | 大环酰胺 L-氨基酸酯 合成 闭环转位反应 琥珀酸酯 L-赖氨酸 L-鸟氨酸 |
| 收稿时间： | 2006-03-06 |
Syntheses of Macrocyclic Amides from L-Amino Acid Esters by RCM |
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| ZHAO Bao-xiang SCHAUDT Marco BLECHERT Siegfried.Syntheses of Macrocyclic Amides from L-Amino Acid Esters by RCM[J].Chemical Research in Chinese University,2007,23(1):22-30. |
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| Authors: | ZHAO Bao-xiang SCHAUDT Marco BLECHERT Siegfried |
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| Institution: | 1. Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China;2. Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623 Berlin, Germany |
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| Abstract: | A series of succinate-derived macrocyclic amides( 1 ) was synthesized via ring-closing metathesis (RCM) as the key step. The substrate included 12 to 15 members. The metathesis precursors were obtained from the amide coupling of tert-butyl 3-carboxyhex-5-enoate(2) with numerous side-chain alkenylated amino acid esters of general type(3)derived from L-lysine and L-ornithine. |
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| Keywords: | Ring-closing metathesis L-Lysine L-Ornithine Allyl succinate Macrocycle |
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