Ruthenium-catalyzed tandem ring closing metathesis (RCM) – atom transfer radical cyclization (ATRC) sequences |
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| Affiliation: | 3. Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada;4. Equipe Structure et Activités des Endotoxines, UMR 8621 du Centre National de la Recherche Scientifique, Institut de Génétique et Microbiologie (IGM), Université de Paris-Sud, 91405 Orsay cedex, France;1. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Pabellón 2, Ciudad Universitaria, C1428EG Buenos Aires, Argentina;3. CONICET – Universidad de Buenos Aires, Unidad de Microanálisis y Métodos Físicos Aplicados a la Química Orgánica (UMYMFOR), Buenos Aires, Argentina;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China |
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| Abstract: | α-ω-Dienes bearing a pendant trichloroacetoxy group undergo a tandem RCM – radical cycloisomerization sequence leading to bicyclic γ-butyrolactones, with both steps of the sequence being catalyzed by ruthenium. |
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