Reaction between isocyanides and dialkyl acetylenedicarboxylates in the presence of 4,5-diphenyl-1,3-dihydro-2H-imidazol-2-one. One-pot synthesis of 5H-imidazo[2,1-b][1,3]oxazine derivatives |
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| Affiliation: | 1. University of Victoria ‐ Genome British Columbia Proteomics Centre, Vancouver Island Technology Park, #3101 – 4464 Markham St., Victoria, BC V8Z 7X8, Canada;2. Department of Biochemistry and Microbiology, University of Victoria, Petch Building Room 207, 3800 Finnerty Rd, Victoria, BC V8P 5C2, Canada |
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| Abstract: | The reactive 1:1 intermediate produced in the reaction between alkyl or aryl isocyanides and dialkyl acetylenedicarboxylates was trapped by 4,5-diphenyl-1,3-dihydro-2H-imidazol-2-one to yield highly functionalized 2,3-diphenyl-5H-imidazo[2,1-b][1,3]oxazine derivatives in fairly good yields. |
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