A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria |
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Authors: | Skirtenko Natalia Richman Michal Nitzan Yeshayahu Gedanken Aharon Rahimipour Shai |
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Institution: | Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel. |
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Abstract: | We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold. |
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