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Yb(OTf)3 catalyzed new cascade reaction: a facile assembly of fused quinazolinones |
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| Authors: | Kumar K Siva Kumar P Mahesh Reddy M Appi Ferozuddin Md Sreenivasulu M Jafar Ahamed A Krishna G R Reddy C Malla Rambabu D Kumar K Shiva Pal Sarbani Pal Manojit |
| Affiliation: | Custom Pharmaceutical Services, Dr Reddy's Laboratories Limited, Bollaram Road Miyapur, Hyderabad 500 049, India. |
| Abstract: | A one-pot Yb(III)-mediated cascade reaction has been developed leading to small molecules based on a novel structural motif, i.e. quinazolin-4-one moiety fused with an isoquinoline ring, for potential inhibition of TNF-α. |
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