Spirocyclic systems derived from pyroglutamic acid |
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| Authors: | Cowley Andrew R Hill Thomas J Kocis Petr Moloney Mark G Stevenson Robert D Thompson Amber L |
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| Affiliation: | Department of Chemistry, Chemistry Research Laboratory, The University of Oxford, Mansfield Road, Oxford, UK OX1 3TA. |
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| Abstract: | The synthesis and likely conformational structure of rigid spirocyclic bislactams and lactam-lactones derived from pyroglutamic acid, and their suitability as lead structures for applications in drug development programmes using cheminformatic analysis, has been investgated. |
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