Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules |
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| Authors: | Kang Do Hyun Jung Ho-Sup Ahn Namyoung Lee Jiseok Seo Sungbaek Suh Kahp-Yang Kim Jinsang Kim Keesung |
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| Affiliation: | School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742, Korea. |
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| Abstract: | We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP(2)) phospholipids. The developed PDA-PIP(2) sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only. |
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