Synthesis of isocoumarin derivatives via the copper-catalyzed tandem sequential cyclization of 2-halo-N-phenyl benzamides and acyclic 1,3-diketones |
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| Authors: | Kavala Veerababurao Wang Cheng-Chuan Barange Deepak Kumar Kuo Chun-Wei Lei Po-Min Yao Ching-Fa |
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| Institution: | Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, ROC. |
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| Abstract: | A facile and rapid synthesis of isocoumarin derivatives using a copper-catalyzed tandem C-C/C-O coupling strategy from readily available substrates is described. The reactions of a wide range of 2-iodo-N-phenyl benzamides and acyclic diketones as starting materials were investigated. |
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