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Formal synthesis of squalamine from desmosterol |
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| Authors: | Okumura Kazuo Nakamura Yutaka Takeuchi Seiji Kato Isao Fujimoto Yoshinori Ikekawa Nobuo |
| Affiliation: | Niigata University of Pharmacy and Applied Life Sciences, Japan. |
| Abstract: | The key intermediate to squalamine, (5alpha,7alpha,24R)-7,24-dihydroxy-cholestan-3-one, was synthesized from the 3-O-acetyl-24R,25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7.4% total yield from the desmosterol derivative. |
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