Covariates of corticotropin-releasing hormone (CRH) concentrations in cerebrospinal fluid (CSF) from healthy humans |
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| Authors: | Email author" target="_blank">James?N?BaraniukEmail author Hilda?Maibach Gail?Whalen Daniel?J?Clauw |
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| Institution: | (1) Division of Rheumatology, Immunology and Allergy, Room GL-002, Lower Level Gorman Building, Georgetown University, 3800 Reservoir Road, DC 20007-2197 Washington, NW;(2) Center for the Advancement of Clinical Research, The University of Michigan, Ann Arbor, MI, USA |
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| Abstract: | Background Define covariates of cerebrospinal corticotropin-releasing hormone (CRH) levels in normal humans. CRHCSF was measured in 9 normal subjects as part of an intensive study of physiological responses stressors in chronic pain and
fatigue states. CRHCSF was first correlated with demographic, vital sign, HPA axis, validated questionnaire domains, baseline and maximal responses
to pain, exercise and other stressors. Significant factors were used for linear regression modeling. |
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