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A dynamic light scattering study of the influence of the phospholipid concentration in a model perfluorocarbon emulsion |
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| Authors: | D De Vleeschauwer P Van der Meeren |
| Institution: | aFaculty of Agricultural and Applied Biological Sciences, Laboratory of Applied Physical Chemistry, University of Ghent, Coupure Links 653, B-9000 Gent, Belgium |
| Abstract: | Perfluorohexyl iodide in water emulsions stabilised by phospholipids were prepared by microfluidisation. Photon correlation spectroscopy revealed that the particle size distributions of these emulsions were bimodal. Centrifugation experiments indicated that the larger mode was caused by the emulsion droplets, whereas the smaller mode was due to phospholipid vesicles formed from the excess amount of phospholipid emulsifier. Comparing the particle size distributions of perfluorocarbon emulsions containing different amounts of phospholipids, it could be concluded that emulsions with a phospholipid/fluorocarbon ratio of 2% at the most were emulsifier limited, whereas those with a ratio of at least 5% were energy input limited. |
| Keywords: | Liposome Emulsion Perfluorocarbon Particle size |
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