Crown ether functionalized magnetic hydroxyapatite as eco‐friendly microvessel inorganic‐organic hybrid nanocatalyst in nucleophilic substitution reactions: an approach to benzyl thiocyanate,cyanide, azide and acetate derivatives

In this paper, high catalytic activity of 4′,4″‐diformyl dibenzo‐18‐crown‐6 anchored onto the functionalized magnetite hydroxyapatite (γ‐Fe₂O₃@HAp–Crown) as a new, versatile and magnetically recoverable catalyst, was prepared. It evaluated as phase‐transfer catalyst and molecular host system for nucleophilic substitution reactions of benzyl halides with thiocyanate, cyanide, azide and acetate anions in water. No evidence for the formation of by‐products was observed and the products obtained in pure form without further purification. The nanocomposite was easily removed from solution via application of a magnetic field, allowing straightforward recovery and reuse. The synthesized nanocomposite was characterized by several techniques such as FT‐IR, TGA‐DTG, EDX, XRD, BET, FE‐SEM, TEM and VSM.