Synthesis and characterization of novel chromone Schiff base complexes as p53 activators |
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| Authors: | Mohamad M.E. Shakdofa Hanan A. Mousa Ammar A. Labib Amira S. Abd‐El‐All Ahmed A. El‐Beih Mohamed M. Abdalla |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science and Arts, Khulais, University of Jeddah, Saudi Arabia;2. Inorganic Chemistry Department, National Research Center, Dokki, Cairo, Egypt;3. Division of Pharmaceutical and Drug Industries, Department Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Cairo, Egypt;4. Research Unit, Saco Pharm. Co., 6th October City, Egypt |
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| Abstract: | A series of chromone Schiff base complexes were prepared and analytically as well as spectroscopically characterized. The ligand was found to act as a monobasic tridentate ligand bonded covalently or coordinatively to the metal ion via deprotonated hydroxyl group, azomethine nitrogen atom and carbonyl oxygen atom of antipyrine moiety. Both electronic spectra and magnetic measurements indicated an octahedral or a distorted octahedral geometry around the metal ions for all metal complexes except the nickel complex, which had a tetrahedral geometry. In addition, the ability of the newly prepared compounds to activate the tumour suppressor p53 in cancer cells was studied, with zinc and copper complexes showing promising activities for p53 ubiquitination compared with diphenylimidazole (reference drug). |
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| Keywords: | benzopyrone metal complexes p53 Schiff base ubiquitin ligase |
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