Pd‐catalyzed Desulfitative reaction of Aryltrifluoroborates with sodium Arenesulfinates in water |
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| Authors: | Sheng Chang Yong Bing Sun Xiu Rong Zhang Lin Lin Dong He Yun Zhu Hong Wei Lai Dan Wang |
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| Institution: | 1. College of Pharmacy, JiLin Medical University, JiLin, JiLin, China;2. National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Nanchang, China;3. College of Pharmacy, Yan Bian University, JiLin, PR, China |
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| Abstract: | An efficient procedure for the synthesis of biaryls was catalyzed by Pd(CH3CN)4(BF4)2 is reported. This Pd‐catalyzed cross‐coupling reaction of aryltrifluoroborates with sodium arenesulfinates was developed under mild and environmentally benign conditions, in water without any ligand or additive. The reaction gave a range of structurally diverse unsymmetrical bi‐aryl molecules with excellent yields, in which the byproduct was sulfur dioxide. It is worth noting that this protocol is also applicable to many heterocyclic aromatics such as thiophene, furan, pyridine, quinoline, isoquinoline and indole. |
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| Keywords: | aryltrifluoroborates Pd‐catalyzed sodium arenesulfinates water |
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