RAPTA complexes containing N‐substituted Tetrazole scaffolds: Synthesis,characterization and Antiproliferative activity |
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Authors: | Poulami Mandal Novina Malviya Bidyut Kumar Kundu Sandeep Singh Dhankhar CM Nagaraja Suman Mukhopadhyay |
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Institution: | 1. Department of Chemistry, School of Basic Sciences, Indian Institute of Technology Indore, Indore, India;2. Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab, India;3. Centre for Bioscience and Biomedical Engineering (BSBE), Indian Institute of Technology Indore, Indore, India |
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Abstract: | This work describes the synthesis of a series of Ru(II)‐Arene (Arene=p‐cymene, benzene) complexes using different N‐substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5‐ triaza‐7‐phospha‐tricyclo‐3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF‐7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo‐pharmacological conditions. |
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Keywords: | antiproliferative activity RAPTA complexes stability study tetrazole scaffolds |
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