In vitro curcumin delivery and antibacterial activity of RuS2 and RuO2 nanoparticles loaded chitosan biopolymer |
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Authors: | Shadi Kheirandish Mehrorang Ghaedi Kheibar Dashtian Faezeh Pourebrahim Ramin Jannesar Vahid Pezeshkpour |
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Institution: | 1. Department of Chemistry, Yasouj University, Yasouj, Iran;2. Department of Pathology, Yasuj University of Medical Sciences, Yasuj, Iran;3. Dena Pathobiology Laboratory, Yasouj, IR, Iran |
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Abstract: | In this work, RuS2 and RuO2 nanoparticles loaded chitosan (Chitosan was extracted from Lobsters shells of Persian Gulf, IR. Iran) was prepared and characterized via FE‐SEM, EDS and FT‐IR analysis. FESEM showed the formation of spherical nanoparticles in size ranging of 20 to 100 mm. Subsequently, the role of these new materials as curcumin drug carrier and in vitro release of curcumin in simulated body fluid (SBF) solution (pH 7.4) were studied. RuS2‐NPs‐CS than to RuO2‐NPs‐CS showed higher drug loading efficiency (>91%) and rapid (<90 min) curcumin drug release in SBF solution. Also, antibacterial activity of RuS2‐NPs‐CS and RuO2‐NPs‐CS in presens and absence of Rosemary extracts against the gram negative bacteria Pseudomonas aeruginosa (PAO 1) was evaluated by detection of minimal inhibition concentration (MIC) and minimal bactericidal concentration (MBC). MIC of RuS2‐NPs‐CS, RuO2‐NPs‐CS and Rosemary extracts on Pseudomonas aeruginosa strains were found to be 50 mg/ml, 50 mg/ml and 1250 mg/ml, respectively. The synergistic effect of these materials for inhibition of PAO 1 growth showed that mixture of RuS2‐NPs‐CS and Rosemary extracts has a better efficiency than to other mixture materials. |
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Keywords: | chitosan curcumin delivery rosemary extracts and Pseudomonas Aeruginosa RuO2‐NPs‐CS RuS2‐NPs‐CS |
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