Graphene‐mesoporous anatase TiO2 nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one‐pot multicomponent synthesis of benzodiazepine derivatives

The potential to bias chemical reaction pathways is a significant goal for physicists and material researchers to design revolutionary materials. Recently, two‐dimensional materials have appeared as a promising candidate for exploring novel catalyst activity in organic reaction. In this context, herein we report an easy and efficient synthesis of substituted benzodiazepines in high yields through the graphene‐based mesoporous TiO₂ nanocomposite (Gr@TiO₂ NCs) catalyst. To validate the merits of the Gr@TiO₂ NCs as a catalyst, we have also designed TiO₂ nanoparticle (NPs) under similar conditions. Successful comprehension realization of Gr@TiO₂ NCs and TiO₂ NPs were concluded from the XRD, SEM, HR‐TEM, EDS elemental mapping, FT‐IR, Raman, UV–Vis and TGA analysis. Gr@TiO₂ NCs has the propitious catalyst performance (~98%) over the TiO₂ NPs (~77%), which could be scrutinized in terms of graphene support toward the TiO₂ NPs and enable the large contact area between graphene and TiO₂ NPs. Incorporated graphene maintaining TiO₂ as a catalytically active and attracting electron to site isolation, as well as protecting TiO₂ from oxidative degradation during the reaction. Moreover, the role of graphene is suggested to prolonged reaction duration, yield and unaltered throughout the reaction because of the π‐π interaction between graphene and TiO₂ NPs. Additionally, the catalyst is recycled by filtration and reprocessed six times without having a significant loss in its catalytic activity.