How Interactions Control Molecular Transport in Channels |
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Authors: | Anatoly B Kolomeisky Karthik Uppulury |
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Institution: | (1) School of Electrical and Computer Engineering, Cornell University, 252 Duffield Hall, Ithaca, NY 14853, USA;(2) Center for Advance Microelectronics and Biomolecular Research, University of Idaho, Post Falls, ID 83854, USA;(3) Wadsworth Center for Labs and Research, Albany, NY 12201, USA |
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Abstract: | The motion of molecules across channels and pores is critically important for understanding mechanisms of many cellular processes.
Here we investigate the mechanism of interactions in the molecular transport through nanopores by analyzing exactly solvable
discrete stochastic models. According to this approach the channel transport is viewed as a set of chemical transitions between
discrete states. It is shown that the strength and spatial distribution of molecule/channel interactions can strongly modify
the particle current. Our analysis indicates that the most optimal transport is achieved when the binding sites are near the
entrance or exit of the pore depending on the sign of interaction potential. In addition, the role of intermolecular interactions
during the channel transport is studied, and it is argued that an increase in the flux can be observed for some optimal interaction
strength. The mechanisms of these phenomena are discussed. |
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