Intramolecular methylation of an allyl sulfone via lithium alkoxyaluminate; application to the enantioselective synthesis of the CD ring of vitamin D3 |
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| Authors: | Sikervar Vikas Fuchs Philip L |
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| Institution: | Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA. |
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| Abstract: | Alcohol-directed intramolecular methylation of an enantiopure allyl sulfone using AlMe(3) provides a trans-hydrindane CD ring alcohol. The substrate cis-CD ring allyl sulfone alcohol is prepared via intramolecular allyl sulfonyl anion addition to aldehyde using Ba(OH)(2). |
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