Continuous-flow synthesis of activated vitamin D3 and its analogues |
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Authors: | Fuse Shinichiro Mifune Yuto Tanabe Nobutake Takahashi Takashi |
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Affiliation: | Department of Applied Chemistry, Tokyo Institute of Technology, 2-12-1, Ookayama, Tokyo 152-8552, Japan. |
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Abstract: | An efficient, two-stage, continuous-flow synthesis of 1α,25-(OH)(2)-vitamin D(3) (activated vitamin D(3)) and its analogues was achieved. The developed method afforded the desired products in satisfactory yields using a high-intensity and economical light source, i.e., a high-pressure mercury lamp. In addition, our method required neither intermediate purification nor high-dilution conditions. |
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