Oxidation of ascorbic acid in the presence of phthalocyanine metal complexes. Chemical aspects of catalytic therapy of cancer 2. Catalysis by cobalt octacarboxyphthalocyanine. Reaction products |
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| Authors: | E G Petrova S A Borisenkova O L Kaliya |
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| Institution: | (1) Federal State Unitary Enterprise State Research Center, “Research Institute of Organic Intermediate Products and Dyes”, building 4, 1 ul. B. Sadovaya, 101999 Moscow, Russian Federation;(2) Department of Chemistry, M. V. Lomonosov Moscow State University, Leninskie Gory, 119899 Moscow, Russian Federation |
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| Abstract: | The products of ascorbic acid oxidation in the presence of cobalt octa-4,5-carboxy-phthalocyanine sodium salt (TPH) were identified. These include the ascorbate radical (A·), hydroxyl radical (OH·), and hydrogen peroxide (H2O2). The kinetics of accumulation and consumption of the reaction products was studied. For the concentration ranges of ascorbic acid
= 0–2.5 ⋅ 10−3 mol L−1 and the catalyst C
TPH = 0–3.5 ⋅ 10−5 mol L−1, the the highest possible concentration of the ascorbate radical is ∼10−7 mol L−1, the concentration of H2O2 is 7 ⋅ 10−4 (30% of the starting concentration of ascorbic acid) and the concentration of the hydroxyl radical is at most 10−6 mol L−1.__________Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2224–2228, October, 2004. |
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| Keywords: | cobalt phthalocyanine ascorbic acid oxidation hydrogen peroxide ascorbate radical hydroxyl radical catalysis cancer therapy |
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