Novel bromotyrosine alkaloids: inhibitors of mycothiol S-conjugate amidase |
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| Authors: | Nicholas G M Newton G L Fahey R C Bewley C A |
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| Affiliation: | Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0820, USA. |
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| Abstract: | [structure: see text] The novel alkaloids 1 and 4 were isolated from an Australian non-verongid sponge, Oceanapia sp. Compound 1 contains an unprecedented imidazolyl-quinolinone substructure attached to a bromotyrosine-derived spiro-isoxazoline. Three other known alkaloids were isolated in addition to 1 and 4 and together represent the first examples of inhibitors of a new mycobacterial enzyme mycothiol S-conjugate amidase (MCA). |
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