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Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties |
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| Authors: | Cummings Maxwell D Lin Tse-I Hu Lili Tahri Abdellah McGowan David Amssoms Katie Last Stefaan Devogelaere Benoit Rouan Marie-Claude Vijgen Leen Berke Jan Martin Dehertogh Pascale Fransen Els Cleiren Erna van der Helm Liesbet Fanning Gregory Van Emelen Kristof Nyanguile Origène Simmen Kenny Raboisson Pierre Vendeville Sandrine |
| Affiliation: | Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mcummin1@its.jnj.com |
| Abstract: | |
| Keywords: | hepatitis C virus inhibitors macrocycles polymerases pharmacokinetics |
| 本文献已被 PubMed 等数据库收录！ | |