Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica |
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| Authors: | Stout E Paige Wang Yong-Gang Romo Daniel Molinski Tadeusz F |
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| Institution: | Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, 92093, USA. |
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| Abstract: | Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors. |
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| Keywords: | alkaloids biosynthesis electron transfer metabiosynthesis natural products |
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