Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes |
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Authors: | Stoeva Savka I Lee Jae-Seung Smith Jennifer E Rosen Steven T Mirkin Chad A |
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Institution: | Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208, USA. |
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Abstract: | We have developed the chemistry for preparing a universal probe and the appropriate nano- and microparticle labels that can be used to do highly selective multiplexed detection of three protein cancer markers at low-femtomolar concentration in buffer and serum media. The approach relies on a new multiplexed version of the biobarcode amplification method and offers new opportunities for studying multiple protein markers in a single sample. This could lead to new forms of disease diagnosis and monitoring disease recurrence in a variety of settings. |
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