Squaric acid ester-based total synthesis of echinochrome A |
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Authors: | Peña-Cabrera Eduardo Liebeskind Lanny S |
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Institution: | Facultada de Química, Universidad de Guanajuanto, Mexico. eduardop@quijote.ugto.mx |
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Abstract: | The total synthesis of echinochrome A is described. Both key intermediates 5 and 8 were efficiently prepared from diisopropyl squarate 7. Nucleophilic addition of aryllithium 8 to 5, followed by thermal ring-expansion/cyclization of the 1,2-adduct 4, furnished hydroquinone 3. Oxidation and full deprotection of 3 gave the title compound. |
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