MODULATION OF INTERFERON-GAMMA-INDUCED HLA-DR EXPRESSION ON THE HUMAN KERATINOCYTE CELL LINE SCC-13 BY ULTRAVIOLET RADIATION |
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Authors: | Islam U Khan Keith D Boehm Craig A Elmets † |
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Institution: | Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA |
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Abstract: | Cell surface expression of major histocompatibility determinants on epidermal keratinocytes is a characteristic feature of a number of inflammatory dermatoses and in all likelihood is caused by diffusion of human leukocyte antigen (HLA)-DR-inducing cytokines from cells present in the dermal mononuclear cell infiltrate. Many of these same disorders respond to ultraviolet(UV) radiation phototherapy. Using the human SCC-13 keratinocyte cell line as a model, UV radiation was found to inhibit interferon-gamma-induced HLA-DR expression. Inhibition correlated closely with decreased steady-state levels of HLA-DR mRNA. These findings provide evidence that the therapeutic effect of UV radiation phototherapy may be mediated by its capacity to down-regulate cytokine-induced keratinocyte HLA-DR expression. |
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